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Our livers have important Cytochrome P450 enzymes (abbreviated CYP450) that metabolize the vast majority of drugs that we take. Cannabinoids like THC and CBD are also metabolized by these enzymes. One of the biggest concerns with patients is how medical marijuana interacts with prescription drugs. Dr. Evan Edwards dives into how cannabis can work with prescriptions, and what to avoid. I will talk with my doctor about effect of CBD oil on my blood pressure medication and see how it can be adjusted.
A low INR implies the certainty of blood clots, but a high INR means there is a risk of CBD gummies for sale bleeding. Warfarin decreases the body’s potential to form blood clots by blocking the formation of vitamin K-dependent coagulation factors. Expert medical advice is highly encouraged before consuming CBD products either as a replacement for a prescribed drug or a nutritional supplement.
Medical professionals are also considering dabigatran as a substitute for warfarin therapy. This is why regular measurement of a user’s international normalized ratio (INR) is necessary, more so when warfarin is taken with CBD. It ensures that the blood levels remain within a narrow range to avoid the side effects brought by warfarin. Warfarin is metabolized by Cytochrome P450, also known as CYP450.
CBD also helps PTSD sufferers stay on top of their mental health by reducing anxiety, stress, depression and other factors that are essential for emotional well-being. This is especially true for combat veterans who want to forget painful memories. It also led to great improvement in sleep quality and less pain during movement. Traditionally, muscles relaxants like Valium are used as quick fixes for muscle tension, soreness, pain, and spasm. But remember most of these muscle medications are either riddled with side effects, ineffective or lead to substance abuse and addiction.
Efforts to isolate the active ingredients in cannabis were made in the 19th century. CBD was studied in 1940 from Minnesota wild hemp and Egyptian Cannabis indica resin. The chemical formula of CBD was proposed from a method for isolating it from wild hemp. Cannabis produces CBD-carboxylic acid through the same metabolic pathway as THC, until the next to last step, where CBDA synthase performs catalysis instead of THCA synthase.
, making it a good replacement for some blood-thinner medications. Since the anticoagulant effect of blood-thinners can be increased with cannabis, many medical professionals advise caution in pairing the two.